A novel class of H(3) antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin

This Letter describes the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin, and the resulting SAR of H(3) antagonism. Multiple rounds of iterative parallel synthesis improved human H(3) IC(50) ~33-fold, and afforded a new class of H(3) antagonists ba...

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Udgivet i:Bioorg Med Chem Lett
Main Authors: Kennedy, J. Phillip, Conn, P. Jeffrey, Lindsley, Craig W.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793969/
https://ncbi.nlm.nih.gov/pubmed/19443215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.04.106
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