Generation mechanism of RANKL(+) effector memory B cells: relevance to the pathogenesis of rheumatoid arthritis

BACKGROUND: The efficacy of B cell-depleting therapies for rheumatoid arthritis underscores antibody-independent functions of effector B cells such as cognate T–B interactions and production of pro-inflammatory cytokines. Receptor activator of nuclear factor κB ligand (RANKL) is a key cytokine invol...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Ota, Yuri, Niiro, Hiroaki, Ota, Shun-ichiro, Ueki, Naoko, Tsuzuki, Hirofumi, Nakayama, Tsuyoshi, Mishima, Koji, Higashioka, Kazuhiko, Jabbarzadeh-Tabrizi, Siamak, Mitoma, Hiroki, Akahoshi, Mitsuteru, Arinobu, Yojiro, Kukita, Akiko, Yamada, Hisakata, Tsukamoto, Hiroshi, Akashi, Koichi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793760/
https://ncbi.nlm.nih.gov/pubmed/26980135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-0957-6
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