Secondary consequences of β-cell inexcitability: Identification and prevention in a murine model of K(ATP)-induced Neonatal Diabetes Mellitus

ATP-insensitive K(ATP) channel mutations cause neonatal diabetes mellitus (NDM). To explore the mechanistic etiology, we generated transgenic mice carrying an ATP-insensitive mutant K(ATP) channel subunit. Constitutive expression in pancreatic β-cells caused neonatal hyperglycemia and progression to...

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Bibliographic Details
Published in:Cell Metab
Main Authors: Remedi, Maria Sara, Kurata, Harley T., Scott, Alexis, Wunderlich, F. Thomas, Rother, Eva, Kleinridders, Andre, Tong, Ailing, Brüning, Jens C., Koster, Joseph C., Nichols, Colin G.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793729/
https://ncbi.nlm.nih.gov/pubmed/19187772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.12.005
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