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Multiple-Objective Optimal Designs for Studying the Dose Response Function and Interesting Dose Levels

We construct an optimal design to simultaneously estimate three common interesting features in a dose-finding trial with possibly different emphasis on each feature. These features are (1) the shape of the dose-response curve, (2) the median effective dose and (3) the minimum effective dose level. A...

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Pubblicato in:Int J Biostat
Autori principali: Hyun, Seung Won, Wong, Weng Kee
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793387/
https://ncbi.nlm.nih.gov/pubmed/26565557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/ijb-2015-0044
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