Lack of tRNA-i6A modification causes mitochondrial-like metabolic deficiency in S. pombe by limiting activity of cytosolic tRNA(Tyr), not mito-tRNA

tRNA-isopentenyl transferases (IPTases) are highly conserved enzymes that form isopentenyl-N(6)-A37 (i6A37) on subsets of tRNAs, enhancing their translation activity. Nuclear-encoded IPTases modify select cytosolic (cy-) and mitochondrial (mt-) tRNAs. Mutation in human IPTase, TRIT1, causes disease...

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Veröffentlicht in:RNA
Hauptverfasser: Lamichhane, Tek N., Arimbasseri, Aneeshkumar G., Rijal, Keshab, Iben, James R., Wei, Fan Yan, Tomizawa, Kazuhito, Maraia, Richard J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793213/
https://ncbi.nlm.nih.gov/pubmed/26857223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.054064.115
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