Upregulation of GSK3β Contributes to Brain Disorders in Elderly REGγ-knockout Mice

GSK3β regulates some functions of the brain, but the mechanisms involved in the maintenance of GSK3β protein stability remain ambiguous. REGγ, an important proteasome activator for ubiquitin-independent protein degradation, has been shown to degrade certain intact proteins and is involved in the reg...

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Publicat a:Neuropsychopharmacology
Autors principals: Lv, Yiqing, Meng, Bo, Dong, Hao, Jing, Tiantian, Wu, Nan, Yang, Yingying, Huang, Lan, Moses, Robb E, O'Malley, Bert W, Mei, Bing, Li, Xiaotao
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793118/
https://ncbi.nlm.nih.gov/pubmed/26370326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.285
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