Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

Ductal occlusion has been postulated to precipitate focal pancreatic inflammation, while the nature of the primary occluding agents has remained elusive. Neutrophils make use of histone citrullination by peptidyl arginine deiminase-4 (PADI4) in contact to particulate agents to extrude decondensed ch...

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Udgivet i:Nat Commun
Main Authors: Leppkes, Moritz, Maueröder, Christian, Hirth, Sebastian, Nowecki, Stefanie, Günther, Claudia, Billmeier, Ulrike, Paulus, Susanne, Biermann, Mona, Munoz, Luis E., Hoffmann, Markus, Wildner, Dane, Croxford, Andrew L., Waisman, Ari, Mowen, Kerri, Jenne, Dieter E., Krenn, Veit, Mayerle, Julia, Lerch, Markus M., Schett, Georg, Wirtz, Stefan, Neurath, Markus F., Herrmann, Martin, Becker, Christoph
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793047/
https://ncbi.nlm.nih.gov/pubmed/26964500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10973
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