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Aging alters bone-fat reciprocity by shifting in vivo mesenchymal precursor cell fate towards an adipogenic lineage

Bone marrow derived mesenchymal progenitor cells (MPCs) play an important role in bone homeostasis. Age-related changes occur in bone resulting in a decrease in bone density and a relative increase in adipocity. Although in vitro studies suggest the existence of an age-related lineage switch between...

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Bibliografische gegevens
Gepubliceerd in:Bone
Hoofdauteurs: Singh, Lakshman, Brennan, Tracy A., Russell, Elizabeth, Kim, Jung-Hoon, Chen, Qijun, Johnson, F. Brad, Pignolo, Robert J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792752/
https://ncbi.nlm.nih.gov/pubmed/26805026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2016.01.014
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