Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer

The Jak/STAT pathway is activated in human pancreatic ductal adenocarcinoma (PDAC) and cooperates with mutant Kras to drive initiation and progression of PDAC in murine models. We hypothesized that the small-molecule Jak2 inhibitor (BMS-911543) would elicit anti-tumor activity against PDAC and decre...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Mace, Thomas A., Shakya, Reena, Elnaggar, Omar, Wilson, Kristin, Komar, Hannah M., Yang, Jennifer, Pitarresi, Jason R., Young, Gregory S., Ostrowski, Michael C., Ludwig, Thomas, Bekaii-Saab, Tanios, Bloomston, Mark, Lesinski, Gregory B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792572/
https://ncbi.nlm.nih.gov/pubmed/26575024
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