A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis

Jacob, the protein encoded by the Nsmf gene, is involved in synapto-nuclear signaling and docks an N-Methyl-D-Aspartate receptor (NMDAR)-derived signalosome to nuclear target sites like the transcription factor cAMP-response-element-binding protein (CREB). Several reports indicate that mutations in...

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Publicado no:PLoS Genet
Main Authors: Spilker, Christina, Nullmeier, Sven, Grochowska, Katarzyna M., Schumacher, Anne, Butnaru, Ioana, Macharadze, Tamar, Gomes, Guilherme M., Yuanxiang, PingAn, Bayraktar, Gonca, Rodenstein, Carolin, Geiseler, Carolin, Kolodziej, Angela, Lopez-Rojas, Jeffrey, Montag, Dirk, Angenstein, Frank, Bär, Julia, D’Hanis, Wolfgang, Roskoden, Thomas, Mikhaylova, Marina, Budinger, Eike, Ohl, Frank W., Stork, Oliver, Zenclussen, Ana C., Karpova, Anna, Schwegler, Herbert, Kreutz, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792503/
https://ncbi.nlm.nih.gov/pubmed/26977770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005907
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