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P-Rex1 promotes resistance to VEGF/VEGFR-targeted therapy in prostate cancer
Autocrine VEGF signaling is critical for sustaining prostate and other cancer stem cells (CSCs) and it is a potential therapeutic target, but we observed that CSCs isolated from prostate tumors are resistant to anti-VEGF (bevacizumab) and anti-VEGFR (sunitinib) therapy. Intriguingly, resistance is m...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4791963/ https://ncbi.nlm.nih.gov/pubmed/26923603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.016 |
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