Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form

Vascular endothelial growth factor-C (VEGF-C) is a potent lymphangiogenic cytokine that signals via the coordinated action of two cell surface receptors, Neuropilin-2 (Nrp2) and VEGFR-3. Diseases associated with both loss and gain of VEGF-C function, lymphedema and cancer, respectively, motivate stu...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Parker, Matthew W., Linkugel, Andrew D., Goel, Hira Lal, Gonzalez, Tingting Wu, Mercurio, Arthur M., Vander Kooi, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394031/
https://ncbi.nlm.nih.gov/pubmed/25752543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.01.018
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