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Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form
Vascular endothelial growth factor-C (VEGF-C) is a potent lymphangiogenic cytokine that signals via the coordinated action of two cell surface receptors, Neuropilin-2 (Nrp2) and VEGFR-3. Diseases associated with both loss and gain of VEGF-C function, lymphedema and cancer, respectively, motivate stu...
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| Pubblicato in: | Structure |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4394031/ https://ncbi.nlm.nih.gov/pubmed/25752543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.01.018 |
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