Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β

The Notch1 and Notch4 signaling pathways regulate endothelial cell homeostasis. Inflammatory cytokines induce the expression of endothelial adhesion molecules, including VCAM1, partly by downregulating Notch4 signaling. We investigated the role of endothelial Notch1 in this IL-1β-mediated process. B...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Verginelli, Federica, Adesso, Laura, Limon, Isabelle, Alisi, Anna, Gueguen, Marie, Panera, Nadia, Giorda, Ezio, Raimondi, Lavinia, Ciarapica, Roberta, Campese, Antonio F., Screpanti, Isabella, Stifani, Stefano, Kitajewski, Jan, Miele, Lucio, Rota, Rossella, Locatelli, Franco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
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Research Paper: Pathology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791227/
https://ncbi.nlm.nih.gov/pubmed/26646450
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