Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo

Rhabdomyosarcoma (RMS) is a paediatric soft-tissue sarcoma arising from skeletal muscle precursors coexpressing markers of proliferation and differentiation. Inducers of myogenic differentiation suppress RMS tumourigenic phenotype. The Notch target gene HES1 is upregulated in RMS and prevents tumour...

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Detalhes bibliográficos
Main Authors: Raimondi, L, Ciarapica, R, De Salvo, M, Verginelli, F, Gueguen, M, Martini, C, De Sio, L, Cortese, G, Locatelli, M, Dang, T P, Carlesso, N, Miele, L, Stifani, S, Limon, I, Locatelli, F, Rota, R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321627/
https://ncbi.nlm.nih.gov/pubmed/22117196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.171
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