Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma

Antiangiogenic therapy resistance occurs frequently in patients with metastatic renal cell carcinoma (RCC). The purpose of this study was to understand the mechanism of resistance to sunitinib, an antiangiogenic small molecule, and to exploit this mechanism therapeutically. We hypothesized that suni...

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發表在:Oncogene
Main Authors: Zhou, Lijun, Liu, Xian-De, Sun, Mianen, Zhang, Xuesong, German, Peter, Bai, Shanshan, Ding, Zhiyong, Tannir, Nizar, Wood, Christopher G, Matin, Surena F, Karam, Jose A, Tamboli, Pheroze, Sircar, Kanishka, Rao, Priya, Rankin, Erinn B., Laird, Douglas A, Hoang, Anh G, Walker, Cheryl L, Giaccia, Amato J, Jonasch, Eric
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791213/
https://ncbi.nlm.nih.gov/pubmed/26364599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.343
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