Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma

Antiangiogenic therapy resistance occurs frequently in patients with metastatic renal cell carcinoma (RCC). The purpose of this study was to understand the mechanism of resistance to sunitinib, an antiangiogenic small molecule, and to exploit this mechanism therapeutically. We hypothesized that suni...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Zhou, Lijun, Liu, Xian-De, Sun, Mianen, Zhang, Xuesong, German, Peter, Bai, Shanshan, Ding, Zhiyong, Tannir, Nizar, Wood, Christopher G, Matin, Surena F, Karam, Jose A, Tamboli, Pheroze, Sircar, Kanishka, Rao, Priya, Rankin, Erinn B., Laird, Douglas A, Hoang, Anh G, Walker, Cheryl L, Giaccia, Amato J, Jonasch, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791213/
https://ncbi.nlm.nih.gov/pubmed/26364599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.343
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