Initial Cleavage of the Human Immunodeficiency Virus Type 1 GagPol Precursor by Its Activated Protease Occurs by an Intramolecular Mechanism

Processing of the GagPol polyprotein precursor of human immunodeficiency virus type 1 (HIV-1) is a critical step in viral assembly and replication. The HIV-1 protease (PR) is translated as part of GagPol and is both necessary and sufficient for precursor processing. The PR is active only as a dimer;...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Pettit, Steven C., Everitt, Lorraine E., Choudhury, Sumana, Dunn, Ben M., Kaplan, Andrew H.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2004
Schlagworte:	Replication
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC479095/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15280456/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.16.8477-8485.2004
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