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Initial Cleavage of the Human Immunodeficiency Virus Type 1 GagPol Precursor by Its Activated Protease Occurs by an Intramolecular Mechanism

Processing of the GagPol polyprotein precursor of human immunodeficiency virus type 1 (HIV-1) is a critical step in viral assembly and replication. The HIV-1 protease (PR) is translated as part of GagPol and is both necessary and sufficient for precursor processing. The PR is active only as a dimer;...

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Udgivet i:J Virol
Principais autores: Pettit, Steven C., Everitt, Lorraine E., Choudhury, Sumana, Dunn, Ben M., Kaplan, Andrew H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC479095/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15280456/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.16.8477-8485.2004
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