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Quantification of nascent transcription by bromouridine immunocapture nuclear run-on RT-qPCR

Nuclear run-on (NRO) is a method that measures transcriptional activity via the quantification of biochemically labelled nascent RNA molecules derived from nuclear isolates. Widespread usage of this technique has been limited due to its technical difficulty relative to steady-state total mRNA analys...

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Détails bibliographiques
Publié dans:Nat Protoc
Auteurs principaux: Roberts, Thomas C., Hart, Jonathan R., Kaikkonen, Minna U., Weinberg, Marc S., Vogt, Peter K., Morris, Kevin V.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4790731/
https://ncbi.nlm.nih.gov/pubmed/26182239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2015.076
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