Basal Core Promoter and Precore Mutations in the Hepatitis B Virus Genome Enhance Replication Efficacy of Lamivudine-Resistant Mutants

During chronic hepatitis B virus (HBV) infection, mutations in the precore (PC) or basal core promoter (BCP) region affecting HBV e antigen (HBeAg) expression occur commonly and represent the predominant virus species in patients with HBeAg-negative chronic hepatitis B. The PC mutation (G1896A+C1858...

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Autores principales: Tacke, Frank, Gehrke, Christina, Luedde, Tom, Heim, Albert, Manns, Michael P., Trautwein, Christian
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC479060/
https://ncbi.nlm.nih.gov/pubmed/15280461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.16.8524-8535.2004
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