Basal Core Promoter and Precore Mutations in the Hepatitis B Virus Genome Enhance Replication Efficacy of Lamivudine-Resistant Mutants

During chronic hepatitis B virus (HBV) infection, mutations in the precore (PC) or basal core promoter (BCP) region affecting HBV e antigen (HBeAg) expression occur commonly and represent the predominant virus species in patients with HBeAg-negative chronic hepatitis B. The PC mutation (G1896A+C1858...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Tacke, Frank, Gehrke, Christina, Luedde, Tom, Heim, Albert, Manns, Michael P., Trautwein, Christian
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2004
Fag:	Replication
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC479060/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15280461/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.16.8524-8535.2004
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