Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of Juvenile Neuronal Ceroid Lipofuscinosis

Batten disease, or juvenile neuronal ceroid lipofuscinosis (JNCL), results from mutations in the CLN3 gene. This disorder presents clinically around the age of five years with visual deficits progressing to include seizures, cognitive impairment, motor deterioration, hallucinations, and premature de...

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Vydáno v:Brain Res
Hlavní autoři: Weimer, Jill M., Benedict, Jared W., Elshatory, Yasser M., Short, Douglas W., Ramirez-Montealegre, Denia, Ryan, Deborah A., Alexander, Noreen A., Federoff, Howard J., Cooper, Jonathan D., Pearce, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4790084/
https://ncbi.nlm.nih.gov/pubmed/17617387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2007.05.018
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