Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of Juvenile Neuronal Ceroid Lipofuscinosis

Batten disease, or juvenile neuronal ceroid lipofuscinosis (JNCL), results from mutations in the CLN3 gene. This disorder presents clinically around the age of five years with visual deficits progressing to include seizures, cognitive impairment, motor deterioration, hallucinations, and premature de...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Brain Res
Prif Awduron: Weimer, Jill M., Benedict, Jared W., Elshatory, Yasser M., Short, Douglas W., Ramirez-Montealegre, Denia, Ryan, Deborah A., Alexander, Noreen A., Federoff, Howard J., Cooper, Jonathan D., Pearce, David A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2007
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4790084/
https://ncbi.nlm.nih.gov/pubmed/17617387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2007.05.018
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