Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation.
Recombinant Mek1 and Raf-1 proteins produced in Sf9 cells undergo a tight association both in vivo and in vitro, which apparently does not depend on additional factors or the kinase activity of Mek1 or Raf-1. The complex can be disrupted by two polyclonal antibodies raised against Raf-1 peptides. Co...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47898/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8248196/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.23.10947 |
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