2-(Quinolin-4-yloxy)acetamides Are Active against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

[Image: see text] 2-(Quinolin-4-yloxy)acetamides have been described as potent in vitro inhibitors of Mycobacterium tuberculosis growth. Herein, additional chemical modifications of lead compounds were carried out, yielding highly potent antitubercular agents with minimum inhibitory concentration (M...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Pissinate, Kenia, Villela, Anne Drumond, Rodrigues-Junior, Valnês, Giacobbo, Bruno Couto, Grams, Estêvão Silveira, Abbadi, Bruno Lopes, Trindade, Rogério Valim, Roesler Nery, Laura, Bonan, Carla Denise, Back, Davi Fernando, Campos, Maria Martha, Basso, Luiz Augusto, Santos, Diógenes Santiago, Machado, Pablo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2016
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789679/
https://ncbi.nlm.nih.gov/pubmed/26985307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00324
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