Discovery of Novel Indoline Cholesterol Ester Transfer Protein Inhibitors (CETP) through a Structure-Guided Approach

[Image: see text] Using the collective body of known (CETP) inhibitors as inspiration for design, a structurally novel series of tetrahydroquinoxaline CETP inhibitors were discovered. An exemplar from this series, compound 5, displayed potent in vitro CETP inhibition and was efficacious in a transge...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Wilson, Jonathan E., Kurukulasuriya, Ravi, Reibarkh, Mikhail, Reiter, Maud, Zwicker, Aaron, Zhao, Kake, Zhang, Fengqi, Anand, Rajan, Colandrea, Vincent J., Cumiskey, Anne-Marie, Crespo, Alejandro, Duffy, Ruth A., Murphy, Beth Ann, Mitra, Kaushik, Johns, Douglas G., Duffy, Joseph L., Vachal, Petr
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2016
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789658/
https://ncbi.nlm.nih.gov/pubmed/26985312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00404
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