COMMON POLYMORPHISMS AT THE CYP17A1 LOCUS ASSOCIATE WITH STEROID PHENOTYPE: SUPPORT FOR BLOOD PRESSURE GWAS SIGNALS AT THIS LOCUS

Genome-wide association studies (GWAS) implicate the CYP17A1 gene in human blood pressure regulation although the causative polymorphisms are as yet unknown. We sought to identify common polymorphisms likely to explain this association. We sequenced the CYP17A1 locus in 60 normotensive individuals a...

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Detalhes bibliográficos
Publicado no:Hypertension
Main Authors: Diver, Louise A., MacKenzie, Scott M., Fraser, Robert, McManus, Frances, Freel, E. Marie, Alvarez-Madrazo, Samantha, McClure, John D., Friel, Elaine C., Hanley, Neil A., Dominiczak, Anna F., Caulfield, Mark J., Munroe, Patricia B., Connell, John M., Davies, Eleanor
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789491/
https://ncbi.nlm.nih.gov/pubmed/26902494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06925
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