C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins

Moderate stress can increase lifespan by hormesis, a beneficial low-level induction of stress response pathways. 5’-fluorodeoxyuridine (FUdR) is commonly used to sterilize Caenorhabditis elegans in aging experiments. However, FUdR alters lifespan in some genotypes and induces resistance to thermal a...

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Publicat a:Mech Ageing Dev
Autors principals: Anderson, Edward N, Corkins, Mark E, Li, Jia-Cheng, Singh, Komudi, Parsons, Sadé, Tucey, Tim M, Sorkaç, Altar, Huang, Huiyan, Dimitriadi, Maria, Sinclair, David A, Hart, Anne C
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789167/
https://ncbi.nlm.nih.gov/pubmed/26854551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2016.01.004
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