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Copy number of the Adenomatous Polyposis Coli gene is not always neutral in sporadic colorectal cancers with loss of heterozygosity for the gene

BACKGROUND: Changes in the number of alleles of a chromosome may have an impact upon gene expression. Loss of heterozygosity (LOH) indicates that one allele of a gene has been lost, and knowing the exact copy number of the gene would indicate whether duplication of the remaining allele has occurred....

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發表在:BMC Cancer
Main Authors: Zauber, Peter, Marotta, Stephen, Sabbath-Solitare, Marlene
格式: Artigo
語言:Inglês
出版: BioMed Central 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788828/
https://ncbi.nlm.nih.gov/pubmed/26970738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2243-z
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