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Cobalt (III) protoporphyrin activates the DGCR8 protein and can compensate microRNA processing deficiency
Processing of microRNA primary transcripts (pri-miRNAs) is highly regulated and defects in the processing machinery play a key role in many human diseases. In 22q11.2 deletion syndrome (22q11.2DS), heterozygous deletion of DiGeorge critical region gene 8 (DGCR8) causes a processing deficiency, which...
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| Pubblicato in: | Chem Biol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4788496/ https://ncbi.nlm.nih.gov/pubmed/26091172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.05.015 |
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