Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response

Peptidyl arginine deiminase 4 (PAD4) is a nuclear enzyme that converts arginine residues to citrulline. Although increasingly implicated in inflammatory disease and cancer, the mechanism of action of PAD4 and its functionally relevant pathways remains unclear. E2F transcription factors are a family...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Ghari, Fatemeh, Quirke, Anne-Marie, Munro, Shonagh, Kawalkowska, Joanna, Picaud, Sarah, McGouran, Joanna, Subramanian, Venkataraman, Muth, Aaron, Williams, Richard, Kessler, Benedikt, Thompson, Paul R., Fillipakopoulos, Panagis, Knapp, Stefan, Venables, Patrick J., La Thangue, Nicholas B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788482/
https://ncbi.nlm.nih.gov/pubmed/26989780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1501257
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