ESCRT-Dependent Cell Death in a Caenorhabditis elegans Model of the Lysosomal Storage Disorder Mucolipidosis Type IV

Mutations in MCOLN1, which encodes the cation channel protein TRPML1, result in the neurodegenerative lysosomal storage disorder Mucolipidosis type IV. Mucolipidosis type IV patients show lysosomal dysfunction in many tissues and neuronal cell death. The ortholog of TRPML1 in Caenorhabditis elegans...

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Detaylı Bibliyografya
Yayımlandı:Genetics
Asıl Yazarlar: Huynh, Julie M., Dang, Hope, Munoz-Tucker, Isabel A., O’Ketch, Marvin, Liu, Ian T., Perno, Savannah, Bhuyan, Natasha, Crain, Allison, Borbon, Ivan, Fares, Hanna
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Genetics Society of America 2016
Konular:
Investigations
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788239/
https://ncbi.nlm.nih.gov/pubmed/26596346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.115.182485
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