PGC-1α Induces Human RPE Oxidative Metabolism and Antioxidant Capacity

PURPOSE: Oxidative stress and metabolic dysregulation of the RPE have been implicated in AMD; however, the molecular regulation of RPE metabolism remains unclear. The transcriptional coactivator, peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) is a powerful mediator of mitoc...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Iacovelli, Jared, Rowe, Glenn C., Khadka, Arogya, Diaz-Aguilar, Daniel, Spencer, Carrie, Arany, Zoltan, Saint-Geniez, Magali
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2016
Témata:
Retinal Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788093/
https://ncbi.nlm.nih.gov/pubmed/26962700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-17758
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