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Local sequence assembly reveals a high-resolution profile of somatic structural variations in 97 cancer genomes

Genomic structural variations (SVs) are pervasive in many types of cancers. Characterizing their underlying mechanisms and potential molecular consequences is crucial for understanding the basic biology of tumorigenesis. Here, we engineered a local assembly-based algorithm (laSV) that detects SVs wi...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Zhuang, Jiali, Weng, Zhiping
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4787836/
https://ncbi.nlm.nih.gov/pubmed/26283183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv831
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