Trivalent Gd-DOTA reagents for modification of proteins

The development of novel protein-targeted MRI contrast agents crucially depends on the ability to derivatise suitable targeting moieties with a high payload of relaxation enhancer (e.g., gadolinium(iii) complexes such as Gd-DOTA), without losing affinity for the target proteins. Here, we report robu...

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Veröffentlicht in:RSC Adv
Hauptverfasser: Fisher, Martin J., Williamson, Daniel J., Burslem, George M., Plante, Jeffrey P., Manfield, Iain W., Tiede, Christian, Ault, James R., Stockley, Peter G., Plein, Sven, Maqbool, Azhar, Tomlinson, Darren C., Foster, Richard, Warriner, Stuart L., Bon, Robin S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2015
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786947/
https://ncbi.nlm.nih.gov/pubmed/27019702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ra20359g
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