Trivalent Gd-DOTA reagents for modification of proteins

The development of novel protein-targeted MRI contrast agents crucially depends on the ability to derivatise suitable targeting moieties with a high payload of relaxation enhancer (e.g., gadolinium(iii) complexes such as Gd-DOTA), without losing affinity for the target proteins. Here, we report robu...

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Detalhes bibliográficos
Publicado no:RSC Adv
Main Authors: Fisher, Martin J., Williamson, Daniel J., Burslem, George M., Plante, Jeffrey P., Manfield, Iain W., Tiede, Christian, Ault, James R., Stockley, Peter G., Plein, Sven, Maqbool, Azhar, Tomlinson, Darren C., Foster, Richard, Warriner, Stuart L., Bon, Robin S.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2015
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786947/
https://ncbi.nlm.nih.gov/pubmed/27019702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ra20359g
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