Trivalent Gd-DOTA reagents for modification of proteins

The development of novel protein-targeted MRI contrast agents crucially depends on the ability to derivatise suitable targeting moieties with a high payload of relaxation enhancer (e.g., gadolinium(iii) complexes such as Gd-DOTA), without losing affinity for the target proteins. Here, we report robu...

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Enregistré dans:
Détails bibliographiques
Publié dans:RSC Adv
Auteurs principaux: Fisher, Martin J., Williamson, Daniel J., Burslem, George M., Plante, Jeffrey P., Manfield, Iain W., Tiede, Christian, Ault, James R., Stockley, Peter G., Plein, Sven, Maqbool, Azhar, Tomlinson, Darren C., Foster, Richard, Warriner, Stuart L., Bon, Robin S.
Format: Artigo
Langue:Inglês
Publié: Royal Society of Chemistry 2015
Sujets:
Chemistry
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786947/
https://ncbi.nlm.nih.gov/pubmed/27019702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ra20359g
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