Trivalent Gd-DOTA reagents for modification of proteins

The development of novel protein-targeted MRI contrast agents crucially depends on the ability to derivatise suitable targeting moieties with a high payload of relaxation enhancer (e.g., gadolinium(iii) complexes such as Gd-DOTA), without losing affinity for the target proteins. Here, we report robu...

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Bibliografische gegevens
Gepubliceerd in:RSC Adv
Hoofdauteurs: Fisher, Martin J., Williamson, Daniel J., Burslem, George M., Plante, Jeffrey P., Manfield, Iain W., Tiede, Christian, Ault, James R., Stockley, Peter G., Plein, Sven, Maqbool, Azhar, Tomlinson, Darren C., Foster, Richard, Warriner, Stuart L., Bon, Robin S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Royal Society of Chemistry 2015
Onderwerpen:
Chemistry
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786947/
https://ncbi.nlm.nih.gov/pubmed/27019702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ra20359g
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