Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4(+) T Cells

The inherent risks associated with vector insertion in gene therapy need to be carefully assessed. We analyzed the genome-wide distributions of Sleeping Beauty (SB) and piggyBac (PB) transposon insertions as well as MLV retrovirus and HIV lentivirus insertions in human CD4(+) T cells with respect to...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Ther
Auteurs principaux: Gogol-Döring, Andreas, Ammar, Ismahen, Gupta, Saumyashree, Bunse, Mario, Miskey, Csaba, Chen, Wei, Uckert, Wolfgang, Schulz, Thomas F, Izsvák, Zsuzsanna, Ivics, Zoltán
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786924/
https://ncbi.nlm.nih.gov/pubmed/26755332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.11
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