Re-expression of Selected Epigenetically Silenced Candidate Tumor Suppressor Genes in Cervical Cancer by TET2-directed Demethylation

DNA hypermethylation is extensively explored as therapeutic target for gene expression modulation in cancer. Here, we re-activated hypermethylated candidate tumor suppressor genes (TSGs) (C13ORF18, CCNA1, TFPI2, and Maspin) by TET2-induced demethylation in cervical cancer cell lines. To redirect TET...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Huisman, Christian, van der Wijst, Monique G P, Schokker, Matthijs, Blancafort, Pilar, Terpstra, Martijn M, Kok, Klaas, van der Zee, Ate G J, Schuuring, Ed, Wisman, G Bea A, Rots, Marianne G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786921/
https://ncbi.nlm.nih.gov/pubmed/26686387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.226
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