Direct Interaction between the Voltage Sensors Produces Cooperative Sustained Deactivation in Voltage-gated H(+) Channel Dimers

The voltage-gated H(+) channel (Hv) is a voltage sensor domain-like protein consisting of four transmembrane segments (S1–S4). The native Hv structure is a homodimer, with the two channel subunits functioning cooperatively. Here we show that the two voltage sensor S4 helices within the dimer directl...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Okuda, Hiroko, Yonezawa, Yasushige, Takano, Yu, Okamura, Yasushi, Fujiwara, Yuichiro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786727/
https://ncbi.nlm.nih.gov/pubmed/26755722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.666834
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