Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis

Increased APP (amyloid precursor protein) processing causes β-amyloid (Aβ) accumulation in autosomal dominant Alzheimer's disease (AD), but it is unclear if it also affects sporadic Aβ accumulation. We tested healthy controls and patients with mild cognitive symptoms (N=331) in the BioFINDER st...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Mattsson, Niklas, Insel, Philip S., Palmqvist, Sebastian, Stomrud, Erik, van Westen, Danielle, Minthon, Lennart, Zetterberg, Henrik, Blennow, Kaj, Hansson, Oskar
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786682/
https://ncbi.nlm.nih.gov/pubmed/26948379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10918
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