Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed osteoblastic bone formation is mostly unknown. Here, we show that increased os...

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Pubblicato in:Nat Commun
Autori principali: Li, Defang, Liu, Jin, Guo, Baosheng, Liang, Chao, Dang, Lei, Lu, Cheng, He, Xiaojuan, Cheung, Hilda Yeuk-Siu, Xu, Liang, Lu, Changwei, He, Bing, Liu, Biao, Shaikh, Atik Badshah, Li, Fangfei, Wang, Luyao, Yang, Zhijun, Au, Doris Wai-Ting, Peng, Songlin, Zhang, Zongkang, Zhang, Bao-Ting, Pan, Xiaohua, Qian, Airong, Shang, Peng, Xiao, Lianbo, Jiang, Baohong, Wong, Chris Kong-Chu, Xu, Jiake, Bian, Zhaoxiang, Liang, Zicai, Guo, De-an, Zhu, Hailong, Tan, Weihong, Lu, Aiping, Zhang, Ge
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786676/
https://ncbi.nlm.nih.gov/pubmed/26947250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10872
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