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A discrete-time survival model with random effects for designing and analyzing repeated low-dose challenge experiments
Repeated low-dose (RLD) challenge designs are important in HIV vaccine research. Current methods for RLD designs rely heavily on an assumption of homogeneous risk of infection among animals, which, upon violation, can lead to invalid inferences and underpowered study designs. We propose to fit a dis...
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| Pubblicato in: | Biostatistics |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4786638/ https://ncbi.nlm.nih.gov/pubmed/25190513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxu040 |
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