Hypoxia attenuates Hsp90 inhibitor 17-DMAG-induced cyclin B1 accumulation in hepatocellular carcinoma cells

Hypoxia stress plays a pivotal role in tumor formation, proliferation, and invasion. Conventional chemotherapy is less effective in the hypoxia microenvironment of solid tumor. Heat shock protein 90 (Hsp90) is an important molecular chaperone in cancer cells and has been a pharmaceutical target for...

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Bibliographic Details
Published in:Cell Stress Chaperones
Main Authors: Zhang, Jianming, Li, Huadan, Huang, Zhizhou, He, Yangfan, Zhou, Xueqiong, Huang, Tingyuan, Dai, Peijuan, Duan, Danping, Ma, Xiaojiao, Yin, Qiangbin, Wang, Xiaojie, Liu, Hong, Chen, Size, Zou, Fei, Chen, Xuemei
Format: Artigo
Language:Inglês
Published: Springer Netherlands 2016
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786521/
https://ncbi.nlm.nih.gov/pubmed/26786409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-015-0664-2
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