Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein

Inflammation and oxidative and dicarbonyl stress play important roles in the pathogenesis of type 2 diabetes. Metformin is the first-line drug of choice for the treatment of type 2 diabetes because it effectively suppresses gluconeogenesis in the liver. However, its “pleiotropic” effects remain cont...

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Udgivet i:PLoS One
Main Authors: Malínská, Hana, Oliyarnyk, Olena, Škop, Vojtěch, Šilhavý, Jan, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šimáková, Miroslava, Strnad, Hynek, Kazdová, Ludmila, Pravenec, Michal
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786274/
https://ncbi.nlm.nih.gov/pubmed/26963617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150924
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