A New Application of Parallel Synthesis Strategy for Discovery of Amide-Linked Small Molecules as Potent Chondroprotective Agents in TNF-α-Stimulated Chondrocytes

As part of an effort to profile potential therapeutics for the treatment of inflammation-related diseases, a diversity of amide-linked small molecules was synthesized by using parallel synthesis strategy. Moreover, these new compounds were also evaluated for their inhibitory effects on nitric oxide...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Lee, Chia-Chung, Lo, Yang, Ho, Ling-Jun, Lai, Jenn-Haung, Lien, Shiu-Bii, Lin, Leou-Chyr, Chen, Chun-Liang, Chen, Tsung-Chih, Liu, Feng-Cheng, Huang, Hsu-Shan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786219/
https://ncbi.nlm.nih.gov/pubmed/26963090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149317
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