Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice

Prox1 heterozygous mice have a defective lymphatic vasculature and develop late-onset obesity. Chyle abnormally leaks from those vessels, accumulates in the surrounding tissues, and causes an increase in adipose tissue. We characterized the lymphatics of Prox1(+/–) mice to determine whether the exte...

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Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Escobedo, Noelia, Proulx, Steven T., Karaman, Sinem, Dillard, Miriam E., Johnson, Nicole, Detmar, Michael, Oliver, Guillermo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786184/
https://ncbi.nlm.nih.gov/pubmed/26973883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85096
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