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Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice
Prox1 heterozygous mice have a defective lymphatic vasculature and develop late-onset obesity. Chyle abnormally leaks from those vessels, accumulates in the surrounding tissues, and causes an increase in adipose tissue. We characterized the lymphatics of Prox1(+/–) mice to determine whether the exte...
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| 發表在: | JCI Insight |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Clinical Investigation
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4786184/ https://ncbi.nlm.nih.gov/pubmed/26973883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85096 |
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