Specific Activation of A(3), A(2A) and A(1) Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration

CD73 (ecto-5'-nucleotidase), a cell surface enzyme hydrolyzing AMP to adenosine, was lately demonstrated to play a direct role in tumor progression including regulation of tumor vascularization. It was also shown to stimulate tumor macrophage infiltration. Interstitial adenosine, accumulating i...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Koszałka, Patrycja, Gołuńska, Monika, Urban, Aleksandra, Stasiłojć, Grzegorz, Stanisławowski, Marcin, Majewski, Marceli, Składanowski, Andrzej C., Bigda, Jacek
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786137/
https://ncbi.nlm.nih.gov/pubmed/26964090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151420
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