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Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation
Activation of epidermal growth factor receptor (EGFR), which occurs in many types of tumour, promotes tumour progression(1,2). However, no extracellular antagonist of human EGFR has been identified. We found that human macrophage migration inhibitory factor (MIF) is O-GlcNAcylated at Ser 112/Thr 113...
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| Publicado no: | Nat Cell Biol |
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| Principais autores: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4785887/ https://ncbi.nlm.nih.gov/pubmed/26280537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3222 |
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