Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation

Activation of epidermal growth factor receptor (EGFR), which occurs in many types of tumour, promotes tumour progression(1,2). However, no extracellular antagonist of human EGFR has been identified. We found that human macrophage migration inhibitory factor (MIF) is O-GlcNAcylated at Ser 112/Thr 113...

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Udgivet i:Nat Cell Biol
Main Authors: Zheng, Yanhua, Li, Xinjian, Qian, Xu, Wang, Yugang, Lee, Jong-Ho, Xia, Yan, Hawke, David H., Zhang, Gang, Lyu, Jianxin, Lu, Zhimin
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785887/
https://ncbi.nlm.nih.gov/pubmed/26280537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3222
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