Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation

Activation of epidermal growth factor receptor (EGFR), which occurs in many types of tumour, promotes tumour progression(1,2). However, no extracellular antagonist of human EGFR has been identified. We found that human macrophage migration inhibitory factor (MIF) is O-GlcNAcylated at Ser 112/Thr 113...

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Detaylı Bibliyografya
Yayımlandı:Nat Cell Biol
Asıl Yazarlar: Zheng, Yanhua, Li, Xinjian, Qian, Xu, Wang, Yugang, Lee, Jong-Ho, Xia, Yan, Hawke, David H., Zhang, Gang, Lyu, Jianxin, Lu, Zhimin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785887/
https://ncbi.nlm.nih.gov/pubmed/26280537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3222
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