Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation

Activation of epidermal growth factor receptor (EGFR), which occurs in many types of tumour, promotes tumour progression(1,2). However, no extracellular antagonist of human EGFR has been identified. We found that human macrophage migration inhibitory factor (MIF) is O-GlcNAcylated at Ser 112/Thr 113...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Nat Cell Biol
Main Authors: Zheng, Yanhua, Li, Xinjian, Qian, Xu, Wang, Yugang, Lee, Jong-Ho, Xia, Yan, Hawke, David H., Zhang, Gang, Lyu, Jianxin, Lu, Zhimin
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785887/
https://ncbi.nlm.nih.gov/pubmed/26280537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3222
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla